<p>Ataxia-Telangiectasia Mutated (ATM) protein is essential for rapid induction of the cellular response to DNA double strand breaks. The C-terminal portion of ATM contains a kinase domain, which shares homology with phosphatidylinositol-3 kinase (PI3K) and is activated by DNA double strand breaks. The N-terminal portion of ATM is required for DNA-binding activity and is thought to be important for association of the protein to the site of DNA damage [<cite idref="PUB00034785"/>]. Mutations in the ATM gene are the principal cause of the disease Ataxia-Telangiectasia, for which the gene is named [<cite idref="PUB00034786"/>].</p> <p>Proteins in this subfamily are known human ATM proteins or share homology with known ATM proteins.</p> <p>Synonym(s): ATM </p> Ataxia-Telangiectasia Mutated